In a non-peer-reviewed research paper just this week published, Stephanie Seneff, Ph.D., describes a mechanism of the COVID shots that results in the suppression of your innate immune system. It does this by inhibiting the type-1 interferon pathway.

In this interview, return guest Stephanie Seneff, Ph.D., a senior research scientist at MIT who has been at MIT for over five decades, discusses her latest paper, “Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations. The Role of G-quadruplexes, Exosomes and MicroRNAs,” co-written with Dr. Peter McCullough, along with two other authors, Dr. Greg Nigh and Dr. Anthony Kyriakopoulos.

Previously, Nigh and Seneff co-wrote an entire paper detailing the differences between the spike protein and the COVID jab spike protein. In a non-peer-reviewed research paper just this week published on the pre-print service authorea, they and their other co-authors delve deeply into the mechanisms of the COVID shots, showing how they absolutely, in no way, shape or form, are safe or effective. The shots actually suppress your innate immune system.

“I think McCullough is fantastic and I’m so happy to have him collaborate with me,” Seneff says. “I really hope we will be able to find a journal that is willing to publish it. We may have to seek some kind of alternative media to get it published.

It’s really incredible the amount of censorship that’s going on right now. I’m in a state of shock all the time. I just keep thinking it’s not going to get any worse, and it’s truly going to get better, and it just seems to keep on getting worse and worse.

I don’t know where the end is. It’s very discouraging … Pharma has so much money behind [them] and they’ve got it all set up to make sure that nothing gets past them …

We’re hoping to put it up as a preprint, but … remarkably, they can reject it at the level of preprint as well. We’re working on that angle, but it’s not easy. When you’re writing something this radical, they really fight hard to keep it off the web.”

On Jan. 16, 2022, the pre-print service Authorea published this paper on its web site, assigning it a DOI, thus making it official.

Exceptionally Strong Safety Signals
As noted by Seneff, when you look at the various databases for adverse effects, you can see an exceptionally strong safety signal—and the COVID shot developers know that. “The numbers are out of sight,” Seneff says, and this goes for all levels of side effects, from mild to catastrophic.

Seneff has been looking at the cancer data, for example, and on average, there are twice as many reports of cancer following the COVID shots compared to all other vaccines combined over the last 31 years.

“It’s just amazing, because it’s overall two times [higher]. Breast cancer, for example, is three times [higher] for these vaccines in one year, as they are for all the other vaccines for 31 years. It’s a hugely strong signal,” Seneff says.

“Lymphoma is also showing up much more frequently with these [COVID shots]. There’s just an amazing signal there in VAERS [the U.S. Vaccine Adverse Events Reporting System].”

The fact that the signal is that strong is even more remarkable when you consider that most people don’t think the COVID shot could be a variable in their cancer emergence, so they never report it. “It puzzles me that they’re willing to do such damage to the health of the whole population of the world. I don’t understand that degree of evilness,” Seneff says.

Type-1 Interferon Disruption
The shots suppress your innate immune system by inhibiting type-1 interferon. One of the first studies to tip off Seneff and McCullough to this was an Indian study, in which human cells grown in a culture were exposed to the DNA nanoparticles that instruct them to make SARS-CoV-2 spike protein, much like the COVID shots do.

The cell strain is called HEK-293. These are cells that were taken from the kidneys of an aborted fetus in the 1980s and are frequently used in research. While taken from the kidneys, these cells have neuron-like properties. When programmed to make spike protein, these cells release that spike protein inside exosomes — lipid nanoparticles inside which the spike protein is packaged.

Exosomes act as a communication network for cells. When a cell is under stress, it releases exosomes containing some of the molecules that are stressing it. So, in the case of the COVID shots, the exosomes contain spike protein and microRNA. MicroRNAs are signaling molecules that are able to influence cell function. They cause the cell to change its behavior or metabolism. Typically, they do this by suppressing certain enzymes.

The Indian study found two specific microRNAs inside the exosomes released by these neuron-like cells: miR-148a and miR-590. The researchers then exposed microglia (immune cells in your brain) to these exosomes. So, as explained by Seneff, you’ve got neurons in your brain producing spike protein, or taking up spike protein that is in circulation, and reacting to it by releasing exosomes.

The exosomes are then picked up by microglia, the immune cells in your brain. When the immune cells receive those exosomes, they turn on an inflammatory response. This is primarily a response to those microRNAs, the miR-148a and miR-590. Of course, you also have the toxic spike protein there.

Combined, they cause inflammation in the brain, which damages neurons. This inflammation, in turn, can contribute to a number of degenerative brain disorders. The lipid particles in the COVID shot, which contain the mRNA, are similar to exosomes, but not identical. They’re also very similar to low-density lipid (LDL) particles.

“I think the exosomes are probably quite a bit smaller. The vaccine particles are bigger. They’re more like an LDL particle. The vaccine particles have cholesterol in their membrane, and they have lipoprotein. So, they’re made to look like an LDL particle.

But then they throw in this cationic lipid, which is really, really toxic — a synthetic cationic lipid that makes it positively charged. Experimentally, they’ve found that this lipid, when the particle is taken up by the cell, is released into the cytoplasm, [where] that mRNA then makes spike protein.

[The COVID shots] are very cleverly designed, both in terms of protecting the RNA from getting broken down, and in terms of making the RNA be very efficient at making spike protein. It’s very different from the mRNA that the virus makes, even though it codes for the same protein.”

Seneff wrote an entire paper detailing the differences between the viral spike protein and the COVID jab spike protein, together with Greg Nigh, which was published in the International Journal of Vaccine Theory, Practice and Research in May 2021. It basically serves as a primer for understanding what we discuss here.

Two microRNAs, miR-148a and miR-590—excreted in the exosomes along with the spike protein—significantly disrupt the type-1 interferon response in any cell, including immune cells.
Getting back to the Indian paper cited above, they found that the microglia ended up producing inflammation in the brain, and the two microRNAs were central in this process. The miR-148a and miR-590 were put into those exosomes with the spike protein, and these two microRNAs are able to significantly disrupt the type-1 interferon response in any cell, including immune cells.

Type-1 interferon also keeps latent viruses like herpes and varicella (which causes shingles) viruses in check, so if your interferon pathway is suppressed, these latent viruses can also start to emerge. The VAERS database reveals many who have been jabbed do report these kinds of infections. Suppressed interferon also raises your risk of cancer and cardiovascular disease.

Type-1 Interferon Response Is Crucial in Viral Infections
As explained by Seneff, the type-1 interferon response is absolutely crucial as the first-stage response to a viral infection. When a cell is invaded by a virus, it releases type-1 interferon alpha and type-1 interferon beta. They act as signaling molecules that tell the cell that it’s been infected.

That, in turn, launches the immune response and gets it going early in the viral infection. It’s been shown that people who end up with severe SARS-CoV-2 infection have a compromised type-1 interferon response. As noted by Seneff:

“It’s ironic that the vaccines are being given to protect you from COVID, yet, they produce a situation where your immune cells are ill-equipped to fight SARS-CoV-2 if it gets into the cell. The trick is, the vaccine produces a tremendous antibody response, and that’s typical of severe disease.

So, the [COVID shot] fools your immune system into thinking that you’ve had a severe case of COVID. It’s really interesting that way, because it’s gotten past the mucosal barrier of the lungs, it’s gotten past the vascular barrier of the blood, into the muscle. Also, it’s been disguised.

The RNA doesn’t look like a virus RNA, it looks like a human RNA molecule. Part of the modifications [made to the mRNA in the jab] was to make it very sturdy, so it can’t be broken down. It’s also very good at making [spike] protein fast, which also has a problem because it leads to a lot of errors, which is another issue …

The immune cells take up the nanoparticles and carry them through the lymph system into the spleen. Multiple studies have shown that it ends up in the spleen … the ovaries, the liver, the bone marrow … The spleen, of course, is very important for producing antibodies.”

Importantly, the antibody response you get from the COVID shot is exponentially higher than what you get from natural infection, and research has shown that the level of antibody response rises with disease severity. So, the shot basically mimics severe infection. In mild infection, you may not produce any antibodies at all, because the innate immune cells are strong enough to fight off the infection without them.

It’s when your innate immune system is weak that you get into trouble, and part of that weakness is a suppressed type-1 interferon response. If your type-1 interferon response is deficient, your immune cells are not very capable of stopping the spread of the virus in your body.

According to Seneff, the reason type-1 interferon supplementation has not been recommended thus far is because you have to time it perfectly in order for the immune cascade to function properly. Type-1 interferon plays a definitive role only at the very earliest stage of the infection. Once you’ve entered a moderate or severe infection stage, it’s too late to use it.

COVID Shots Confuse Your Immune System
As noted by Seneff, the COVID shots are so unnatural that your immune system doesn’t quite know what to do anymore.

“My impression is that the immune cells don’t know what the hell’s going on. There’s this toxic protein being produced in massive amounts by the immune cells. That’s extremely unusual. There’s no sign of any kind of viral infection because these RNAs look like human RNAs.

It’s as if the human immune cells suddenly decided to make a really toxic protein, and make lots of it — which is exactly what they’re doing — and the immune system is completely baffled by this. The immune cells have no clue what to do with it.

Of course, these immune cells that are overloaded with all this spike protein, they say, ‘I’ve got to get rid of this stuff,’ so they ship it out as these exosomes. The microRNAs [in the exosomes] think that the recipient cells are going to need those particular signaling molecules to help it do whatever it needs to do to cope with this toxic load.

So, you’re spreading the spike protein around to the rest of the body, just to dissipate the toxicity you’re coping with in the spleen, I think. Those exosomes are also very good for training antibodies. There was a nice paper that showed the exosomes being released [have] spike protein in their membrane, the exterior of the exosome.

It’s quite cool that the spike protein is displayed there, because this allows the immune cells — the B-cells and the T-cells that need to get up close and personal to it — to figure out how to shape their antibodies. The antibodies get shaped to match the toxic protein that’s exposed on the surface of the exosomes.

After something like 14 days of the second [jab], the exosomes induced an antibody response. [The researchers] felt the exosomes played a critical role in this extreme antibody response that was produced by the B-cells and the T-cells, the adaptive immune system.

But I think the way the vaccine works is that there’s no game that you can choose other than to make antibodies. It’s the only way you can fight this. It’s a toxic protein that’s being produced and released by these immune cells, and the only thing you can do to stop it is to make antibodies.

They try to make lots and lots of antibodies that will glue onto those toxic spike proteins and block them from being able to get in through the ACE2 receptor. That’s the job of the antibodies. They do a good job of it, initially … It’s true that they do protect you from disease. Unfortunately, the antibody levels drop pretty dramatically, pretty quickly.”

There are also antibodies that enhance disease rather than fight it, and the level of these antibodies declines at a slower pace than the protective antibodies. So, after a number of months you end up with a NEGATIVE immune response. In other words, you’re now more prone to infection than ever before. As explained by Seneff:

“There’s a crossover point at which the enhancing antibodies can be stronger than the protective antibodies, and that’s when you can get this antibody dependent enhancement (ADE) that people have seen in the past with [other] coronavirus vaccines. We’re still trying to see if that’s the case with [the COVID jabs]. There is some evidence here and there, but it’s not [conclusive yet].”

The Importance of Cytotoxic T-Cells
After the India study tipped off Seneff and McCullough to the interferon problem, they came across a Chinese study that tracked the effect of the COVID jab on the immune system over time. Here, they discovered that the infection caused an increase in CD8+ T-cells, important cytotoxic T-cells that actually remove infected cells.

As noted by Seneff, the CD8+ cells are an important part of the defense against SARS-CoV-2. Importantly, CD8+ T-cells were enhanced in response to natural infection, but not in response to the COVID shot. They too found type-1 interferon suppression post-jab. So, in the aftermath of the jab, not only is your first-line response depressed—the type-1 interferon response—but you’re also missing the part of the immune response that cleans away infected cells.

The microRNA That Influences Myocarditis Risk
A third microRNA (mRNA) created by natural SARS-CoV-2 infection is miR-155, and it plays an important role in heart health. Early on in the pandemic, there were reports of COVID-19 causin